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Between 2010-2025 (two examples are provided)
Please add other military uses of nanotechnology and their environmental or health impact 1. Military use 2010-2025:
Question 2: The military is improving uniforms, equipment, weapons, and energy and intelligence systems with nanotech materials. As these are discarded, lost, damaged, and/or altered by use, it is reasonable to assume that nanomaterials may enter the human body and the environment. Your judgment is sought about the research potential posed by the questions below; that is, whether their pursuit is likely to produce knowledge that will lead to the prevention or reduction of potential nanotech environmental pollution and health hazards. Please use the following scale: Potential for gaining new knowledge from the research 5 = Will lead to critical knowledge for preventing and/or reducing problems 4 = Very likely to lead to critical knowledge for preventing and/or reducing problems 3 = May lead to critical knowledge for preventing and/or reducing problems 2 = Not likely to lead to critical knowledge for preventing and/or reducing problems 1 = A complete waste of time Space is provided at the end of each list to add other research questions and/or rephrase any of the given items.
2.1 Health hazard research questions 2.1.1 How are nanoparticles absorbed into the body through the skin, lungs, eyes, ears, and alimentary canal?
5=Will lead to critical knowledge for preventing and/or reducing problems 4=Very likely to lead to critical knowledge for preventing and/or reducing problems 3=May lead to critical knowledge for preventing and/or reducing problems 2=Not likely to lead to critical knowledge for preventing and/or reducing problems 1=A complete waste of time (Click here to choose)
2.1.2 Once in the body, can nanoparticles evade natural defenses of humans and other animals?
2.1.3 How are they distributed throughout the body?
2.1.4 What is unique about the health hazards of manufactured nanomaterials vs. health hazards of particles of a similar size?
2.1.5 What are the important unknowns about nanomaterials passing the brain/blood barriers and transversing neural pathways?
2.1.6 How are nanomaterials metabolized and eliminated by the body?
2.1.7 What is the nature and quantitative effectiveness of the mechanism for removing nanoparticles from the lungs?
2.1.8 Can nanomaterials concentrate inside humans? If so, in which organs are they most likely to accumulate?
2.1.9 Can nanoparticles enter egg and sperm cells altering DNA?
2.1.10 What are the surface properties of nanoparticles that alter toxicity?
Please suggest other key research questions related to health hazards and/or rephrase those above:
2.2.2 Do nanoparticles act like bioaccumulants in Nature?
2.2.3 How biodegradable are nanotube-based structures?
2.2.4 How might nanoparticles get into plants and other organisms?
2.2.5 Could nanoparticles enter the food chain by getting into bacteria and protozoa and accumulate there?
2.2.6 What are the potential environmental impacts of nanotech water purification systems?
2.2.7 How can nanotechnology be used for post-battlefield cleanup (including biological, chemical, and nuclear wastes) so that they do not pollute soil and water?
2.2.8 What strategies could prevent the “gray goo” problem?
Please suggest other key research questions related to environmental pollution and/or rephrase those above:
2.3.2 What are the most useful methodologies and protocols for environmental pollution and health hazard studies for the range of nanotechnologies?
2.3.3 What is a useful classification system to provide a framework to make research judgments and keep track of the state of knowledge about nanotech’s potential pollutions?
2.3.4 How can toxicologists and pharmaceutical scientists investigating nano particles ability to evade cell defenses to target disease be best brought together?
2.3.5 What training will be necessary to provide the capacity for oversight for safer development and application of nanotechnology?
2.3.6 How can nano-built nanoproducts intensify earlier problems of nanomaterials and create important new ones?
2.3.7 How can arms-control measures prevent the deployment of powerful nanomanufacturing systems able to produce unprecedented quantities of advanced weapons?
2.3.8 How can stand-off off-switches be created to deactivate nanotech weapons?
Please suggest other general research questions related to environmental pollution or health hazards and/or rephrase those above::
General Comments:
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