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Military Use 2005-2010
Potential Environmental or Health Impact
Nanomaterials in sun screens, camouflage creams, and/or bioweapons skin shields
Absorption of nanoparticles through the skin and/or flushed into the environment and entering the food chain
Nanomaterials (e.g., nanotubes) in uniforms and equipment to make them stronger and lighter
Nanofiber-like materials that break off from uniforms and equipment and enter the body and environment
Nanoparticles in fuel as additives
Inhalation by military staff but also by the population in general
Nanoparticles as surface coverage to make it harder, smoother, stealthy
Erosion of these nanoparticles make them inhalable by military staff but also by the general population
Nanoparticles in weapons such as depleted uranium
Dispersion in the battlefield leads to transport towards cities and villages for further inhalation by the general population, also redispersion from surfaces of the battlefield
Nanoparticles created by the blast of high technology weapons/high temperature combustion processes
Diseases like cancer, lymphoma or leukemia in humans induced by inhalation of nanopollution or ingestion of contaminated food (also animals) See Twin Towers Collapse Phenomenon – inhaled nano-sized pollution
Nanosensors to detect trace concentrations of biochemicals
Absorption of nanoparticles through the skin into the body and environment, concentrating in water and soil, and eventually linking with natural organisms, causing unknown environmental changes
Nanoparticle accelerants and explosives
Accidental dispersal of nanoparticles into the environment
Aging of items with nanostructured surfaces releases nanoparticles that can be inhaled or digested
Nanopollution in the environment and contamination of environment (vegetables, fruits, etc), humans and animals. The contamination can also infect drinkable water and fish
Radio frequency identification tags to track soldiers and equipment
If implanted in the body could result in materials "leaching" in the body; those in equipment could enter the environment
More effective prophylactics and therapeutics - e.g. time-released polymers that would replace multiple vaccinations
Better control over contracting and spread of illness and disease; however, polymers would end up in the environment
Improved prosthetic devices (non-friction microscopic coatings) and implanted medical devices
Bio-compatibility for these devices and prosthetics has to be established
1.2 Potential Use and Potential Impacts between 2010-2025
Military Use 2010-2025
Potential Environmental or Health Impacts
Artificial blood cells (respirocytes) dramatically enhance human performance
Cause overheating of the body, bio-breakdowns, and their excretion causes another environmental load
Inorganic, non-biodegradable, nanoparticles for drug release or cancer treatment or "permanent" nanosensors
The non-biodegradable nanoparticles (and perhaps also non-biocompatible) can induce a foreign body reaction, "very particular"
Proteomic targeting, genetically selective "designer quasi-viral components", engineered to select specific human targets based on definable genetic markers.
Organisms mutate, creating "biological-grey-goo" pandemic.
Nanoparticles to "clean-up" contaminated areas
They can create new compounds that can have an impact on the environment
Nanoenhanced WMD
WMD effects
Nanocomputers remove humans from the battlefield
Makes warfighting less costly from the side with the tech and therefore makes warfighting more likely
Ubiquitous surveillance systems are deployed without strong controls on the use of information
Psychological stress from the sense of being watched by strangers
Numerous centimeter-scale buoyant platforms are deployed in the atmosphere
Interference with birds and aircraft, precipitation of damaged devices at uncontrolled locations over Earth's surface
Nanoscale time-release bioweapons for inhalation
Potential pollution of air and waterways; long-term effects on those handling the bodies of victims
Large quantities of smart weapons — especially miniaturized, robotic weapons and intelligent, target-seeking ammunition
Death or serious injury to combatants and to civilians. Extensive, potentially polluting destruction of buildings, roads, and infrastructure
Deliberate high-volume production of nano-built weapons and ammunition
Drain on resources (raw materials and energy supply). Insufficient or undeveloped methods of disposal after need for use has passed
Small receptor-enhancers increase alertness and lower the reaction times of humans (Soldiers)
Leads to addiction and/or subsequent Chronic Fatigue Syndrome, leading to weakness, neural damage and death
Nanaoscale biomolecule-driven motors that enhance the efficiency of ATP (Adenosine Triphosphate) usage, the frequency of generation of ATP and increase the life of ATP molecules in endurance athletes and/or long-haul soldiers
Cause overheating of the body, bio-breakdowns, and possibly lead to Rapid-Onset Muscle Soreness after a stipulated duration, and if allowed to function beyond this duration - may kill the organism thus modified
Please add other military uses of nanotechnology and their environmental or health impact Military use 2010-2025:
Question 2: Round 1 asked participants to rate a list of research questions, that if pursued might help prevent or reduce environmental and health impacts. The following scale was used to rate the questions:
The tables below present the averages of the ratings in Round 1. Participants were also asked to suggest additional research questions. These new suggestions are listed following the tables. Using the same scale above, please rate the new suggestions. 2.1 Health hazard research questions – Round 1 ratings sorted by Research Potential
2.1.1 How are nanoparticles absorbed into the body through the skin, lungs, eyes, ears, and alimentary canal?
4.46
2.1.2 Once in the body, can nanoparticles evade natural defenses of humans and other animals? What is the likelihood of immune system recognition of nanomaterials?
4.38
2.1.10 What are the surface properties of nanoparticles that alter toxicity? What are the distinct properties of nanoparticles that may alter toxicity?
3.87
2.1.6 How are nanomaterials metabolized and eliminated by the body?
3.73
2.1.5 What are the important unknowns about nanomaterials passing the brain/blood barriers and transversing neural pathways?
3.64
2.1.4 What is unique about the health hazards of manufactured nanomaterials vs. health hazards of particles of a similar size?
3.60
2.1.8 Can nanomaterials concentrate inside humans? If so, in which organs are they most likely to accumulate?
3.53
2.1.9 Can nanoparticles enter egg and sperm cells altering DNA?
2.1.3 How are they distributed throughout the body?
3.50
2.1.7 What is the nature and quantitative effectiveness of the mechanism for removing nanoparticles from the lungs?
Please rate the additional heath hazard research questions below using the same scale above. 2.1.11 Develop uniform nomenclature for research and presentation of results.
5=Will lead to critical knowledge for preventing and/or reducing problems 4=Very likely to lead to critical knowledge for preventing and/or reducing problems 3=May lead to critical knowledge for preventing and/or reducing problems 2=Not likely to lead to critical knowledge for preventing and/or reducing problems 1=A complete waste of time (Click here to choose)
2.1.12 Do nanoparticles concentrate at critical sites like synapses and tumors?
2.1.13 What are the sizes, aspect ratio, and surface activity determinants of nanoparticle impacts on living organisms (must be studied for specific nanoparticles)?
2.1.14 Effect of exposure to nanoparticles on all lifestages, from fetus to old age, and on all major systems, including neural and immune systems.
2.1.15 Is there built-in auto destruction within the nanoparticles? If so, what happens to the waste materials?
2.1.16 Compared to existing weaponry, how much more deadly will nano-built smart weapons be — especially miniaturized, robotic weapons and intelligent, target-seeking ammunition?
2.1.17 What are potential exposure routes of nanomaterials - both airborne and waterborne?
2.1.18 Are the current toxicity tests used for chemicals appropriate and/or useful for nanomaterials?
2.1.19 How are nanomaterials biotransformed within different species?
2.1.20 Organize data on impacts based on group or class of nanoparticles with respect to chemical composition, size, aspect ratio, and surface activity.
2.1.21 What psychological aspects should be considered?
2.1.22 Investigate regulatory options.
Please suggest other key research questions related to health hazards and/or rephrase those above:
2.2.3 How biodegradable are nanotube-based structures?
4.36
2.2.5 Could nanoparticles enter the food chain by getting into bacteria and protozoa and accumulate there?
4.21
2.2.1 How to identify and dispose of nanomaterial litter?
4.14
2.2.4 How might nanoparticles get into plants and other organisms?
2.2.2 Do nanoparticles act like bioaccumulants in Nature?
4.07
2.2.7 How can nanotechnology be used for post-battlefield cleanup (including biological, chemical, and nuclear wastes) so that they do not pollute soil and water?
4.00
2.2.6 What are the potential environmental impacts of nanotech water purification systems? [Reformulation suggestion: How to determine whether there are environmental impacts of using functionalized nanomaterials or nanostructured membranes or filters for water purification?]
3.93
2.2.8 What strategies could prevent the “gray goo” problem?
2.79
2.2.10 How will nanomaterials enter the environment and will they change when moving from one medium (e.g. air) to another (e.g. water)?
2.2.11 Study current nanoparticle contaminations in post-war fields by high-technology weapons, including smoked cigarette tobacco polluted with depleted uranium.
2.2.12 Are nanoparticles changed in composition, or do they accumulate pollutants in the environment?
2.2.13 How might nanomaterials leach into water tables?
2.2.14 Real inhalation studies (vs. instillation).
2.2.15 Research should be interdisciplinary and international.
2.2.16 Study nanotech impact on ecological systems, and not just on single organisms.
2.2.17 Compared with existing weaponry, how much more damage could nano-built weapons do to buildings, roads, and infrastructure, and how much of a pollution hazard will these create?
2.2.18 What climate change impacts are possible from extremely large-scale operations to provide energy (especially solar) or from mass-produced nano-built weaponry and/or military infrastructure?
2.2.19 What technologies can be used to minimize exposure of nanomaterials?
Please suggest other key research questions related to environmental pollution and/or rephrase those above:
2.3.5 What training will be necessary to provide the capacity for oversight for safe development and application of nanotechnology?
4.17
2.3.2 What are the most useful methodologies and protocols for environmental pollution and health hazard studies for the range of nanotechnologies?
2.3.3 What is a useful classification system to provide a framework to make research judgments and keep track of the state of knowledge about nanotech’s potential pollutions?
2.3.4 How can toxicologists and pharmaceutical scientists investigating nano particles' ability to evade cell defenses to target disease be best brought together?
2.3.1 How can standard metrics for nanotech pollution/hazards be developed?
3.86
2.3.8 How can stand-off off-switches be created to deactivate nanotech weapons?
3.18
2.3.6 How can nano-built nanoproducts intensify earlier problems of nanomaterials and create important new ones?
3.00
2.3.7 How can arms-control measures prevent the deployment of powerful nanomanufacturing systems able to produce unprecedented quantities of advanced weapons?
2.3.10 Can nanoparticles be made preferentially symbiotic with human hosts, creating a new breed of terrorists?
2.3.11 How can specific research into nano-related environmental pollution and health hazards effectively take into account the fundamental ways that all systems (ecological, economic, political, and social) may be disrupted and transformed by molecular manufacturing on local, national, and global scales?
2.3.12 Establish Nanotech-Environmental summits.
2.3.13 What will be the development timeline for nano-built nanomachines (exponential manufacturing) with military potential? How soon do we have to prepare?
2.3.14 How can energy consumption be minimized and waste/pollution be prevented in the manufacturing of nano/military materials and products? This research would address green manufacturing of nanomaterials--applying green chemistry and green engineering principles.
2.3.15 At what stage in the lifecycle of nano/military materials and products do the major environmental impacts occur (e.g., resource extraction, manufacture, use, end of life)? This research would address life cycle assessment of nanomaterials used in military activities.
2.3.16 What are the commonalities between anthropogenic and manufactured particles?
2.3.17 What are the "representative" nanomaterials that should be used for testing in terms of which nanomaterials may result high exposures?
2.3.18 Are there ways to use novel testing methods, protocols and technologies (e.g. toxicogenomics) to increase the efficiency with which we can generate important risk data for new nanomaterials?
Please suggest other general research questions related to environmental pollution or health hazards and/or rephrase those above::
Nanoscience and Nanotechnologies: Opportunities and Uncertainties. Royal Society and the Royal Academy of Engineering, July 2004 http://www.nanotec.org.uk/finalReport.htm
Overview of Completed and Ongoing Activities in the Field: Safety and Risks of Nanotechnology, Version 2.1, Technologie Management, Switzerland (a survey of surveys.) June 10, 2004. http://www.temas.ch/WWWTEMAS/TEMAS_Homepage.nsf/vwRes/Safety/$FILE/NANOSafety_Version2_1.pdf
Vicki L. Colvin. The Potential Impact of Engineered Nanomaterials, Nature Biotechnology, Nature Publishing Group, (10):1166-70, October 2003
From Genomes to Atoms: The Big Down: Atomtech: Technologies Converging at the Nano Scale, The ETC Group, January 2003. – http://www.etcgroup.org/documents/TheBigDown.pdf
Nanotechnology: Small Matter, Many Unknowns, Swiss Reinsurance Company. Zurich, Switzerland, 2004. http://www.swissre.com/INTERNET/pwswpspr.nsf/fmBookMarkFrameSet?ReadForm&BM=../vwAllbyIDKeyLu/ULUR-5YAFFS?OpenDocment
Tom McCarthy, World Systems – http://www.mccarthy.cx/WorldSystem/war.htm
Center for Responsible Nanotechnology, The Effects of Molecular Manufacturing on Military and Government Capability and Planning. – http://www.crnano.org/study20.htm
Nanotechnology: Looking As We Leap, Location: Environmental Health Perspectives, 112 (Sept 2004) A741-749. Main Section of EHP Online – http://ehp.niehs.nih.gov/members/2004/112-13/focus.html
Royal Society and The Royal Academy of Engineering, UK, Nanoscience and nanotechnologies opportunities and uncertainties, new report http://www.nanotec.org.uk/finalReport.htm. The report illustrates the fact that nanotechnologies offer many benefits both now and in the future but that public debate is needed about their development. It also highlights the immediate need for research to address uncertainties about the health and environmental effects of nanoparticles – one small area of nanotechnologies. In particular Chapter 5 addresses issues of health effects and nanotoxicology.
Borm, P.J.A., W.G. Kreyling, Toxicological Hazards of Inhaled Nanoparticles—Potential Implications for Drug Delivery, Journal of Nanoscience and Nanotechnology 4(5): 521-531, 2004. This paper gives a brief review on the toxicology of inhaled nanoparticles, including general principles and current paradigms to explain the special case of nanoparticles in pulmonary toxicology.
Donaldson K, Stone V, Tran L., Kreyling W.G., Borm P. Nanotoxicology: a new frontier in toxicology. Occup Environ Med 2004;61:727–728
Duncan R., The Dawning Era of Polymer Therapeutics, Nature Reviews, 2: 347-359 (May 2003) http://www.nature.com/reviews/drugdisc. Research at the interface of polymer chemistry and the biomedical sciences has given rise to the first nano-sized (5–100 nm) polymer-based pharmaceuticals, the ‘polymer therapeutics’. Polymer therapeutics includes rationally designed macromolecular drugs, polymer–drug and polymer–protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery. The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugates, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomics age.
A.M. Gatti , F. Rivasi, Biocompatibility of micro- and nanoparticles Part I in liver and kidney. Biomaterials June 2002, 23(11): 2381-2387.
A.M. Gatti, Balestri M., Bagni, A. Granulomatosis associated to procelain wear debris, American Journal of Dentistry 2002, 15(6): 369-372.
A.M. Gatti .Biocompatibility of micro- and nano-particles in the colon (part II) Biomaterials , Feb 2004, 25(3): 385-392
M. Lucarelli, E.Monari, AM. Gatti Boraschi Modulation of defence cell funtion by nanoparticles in vitro. Bioceramics n 16. Ed.M.Barbosa , Ed Treans Tech Publ, (ISBN 0-87849-932-6), Porto 2004, 907-910
Peters, Unger, Gatti, Monari, Kirkpatrick, Effects of nano-scaled particles on endothelial cell function in vitro:Studies on viability, proliferation and inflammation, J. of Material Science: Mat. in Medicine. 2004, 15 (4), 321-325
AM. Gatti, Montanari, Monari, Gambarelli, Capitani, Parisini Detection of micro and nanosized biocompatible particles in blood. J. of Mat. Sci. Mat in Med. 15 (4): 469-472, April 2004
AM. Gatti, Montanari The so-called Balkan Syndrome: a bioengieering approach (English version) http://www.idust.net/Docs/Nanoparticles01.htm
AM Gatti, Risk assessment of micro and nanoparticles and the human health, Chapter of Handbook of Nanostructured Biomaterials and their Applications, by American Scientific Publisher USA – in press Dec 2004.
AM Gatti, Symposium Keynote Presentation “Risk Assessment of Nano-Particles and Nano-Technologies for Human Health. 7th World Biomaterials Congress- 2004, 748-749)
Sonia E. Miller, Esq., New York Law Journal Article on Converging Technologies (PDF) The Convergence of N: on Nanotechnology, Nanobiotechnology, and Nanomedicine December 2, 2003 Available at http://www.ctba.us/articles.asp
Safe exponential manufacturing, by Chris Phoenix and Eric Drexler http://www.iop.org/EJ/abstract/0957-4484/15/8/001/ — This paper explains that the so-called ‘gray goo problem’ is now less of a concern than are the implications of other forms of molecular manufacturing. The authors say “Nanotechnology-based fabrication can be thoroughly non-biological and inherently safe: such systems need have no ability to move about, use natural resources, or undergo incremental mutation. Moreover, self-replication is unnecessary: the development and use of highly productive systems of nanomachinery (nanofactories) need not involve the construction of autonomous self-replicating nanomachines. [However,] other concerns present greater problems. Since weapon systems will be both easier to build and more likely to draw investment, the potential for dangerous systems is best considered in the context of military competition and arms control.”
The Wise-Nano project, a collaborative website to study the facts and implications of advanced nanotechnology. It is a site for researchers worldwide to work together, helping to build an understanding of the technologies, their effects, and what to do about them. http://wise-nano.org
Chiu-Wing Lam, John T. James, Richard McCluskey, and Robert L. Hunter, Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days after Intratracheal Instillation, Toxicological Sciences, 2004, 77:126--134
D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Webb, Comparative Pulmonary Toxicity Assessment of Single-Wall Carbon Nanotubes in Rats, Toxicological Sciences, 2004, 77:117-125)
Kevin L. Dreher, Health and Environmental Impact of Nanotechnology: Toxicological Assessment of Manufactured Nanoparticles, Toxicological Sciences, 2004, 77:3-5
Joe Pappalardo, Military Ponders Future of Nanotech, National Defense, October 2004
Mihail C. Roco and WIlliam Sims (ed.), Societal Implications of Nanoscience and Nanotechnology, Bainbridge, Kluwer Academic Publishers
Wolfgang Luther editor, Industrial Application of Nanomaterials - Chances and Risks, Technological Analysis (with support of the European Commission), Published by Future Technologies Division, Graf-Recke-Str. 84, Germany. http://www.zukuenftigetechnologien.de/11.pdf
Additional Comments:
Thank you very much for your participation. The results will be sent to you in several months, and will be available later in the 2005 State of the Future.